Recent Advances in Solid Lipid Nanoparticle Based Drug Delivery Systems
نویسنده
چکیده
Delivering the drug accurately and safely to its target site at the precise time period to have a controlled release and attain the maximum therapeutic effect remains a benchmark in the design and development of newer drug delivery systems. In this review, the latest research developments of the Solid lipid nanoparticles (SLNs) according to the recent relevant literatures were focussed. This paper highlights various production techniques for SLNs as well as their advantages and disadvantages. Analytical techniques for characterization of SLNs like electron microscopy, dynamic light scattering, atomic force microscopy, differential scanning calorimetry, X-ray diffraction, nuclear magnetic resonance and electron spin resonance are discussed. Aspects of principles of drug release and different administration routes of SLNs were described. These SLNs have been claimed to overcome the shortcomings of other colloidal drug delivery systems.
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